Neural stem cells(NSCs) are considered a heterogeneous population of mitotically active, self-renewing, multipotent, immature progenitor cells, which have the potential to proliferate into neurons, astroglia and oligodendroglia.
For a long time, people thought that mamalian neural stem cells did not have the potential to self renew, which meant once damaged they did not regenerate. This conception is a huge obstacle for the treatment of Parkinson's Disease, Multiple Sclerosis, cerebral injury and spinal cord injury.
The Key Features of NSCs:
1)Self-renewable: Self-proliferation and self renew is the basic property of NSCs. NSCs could divide by asymmetric and symmetric division to maintain the stability of cell bank.
2)Multi-directional differentiation: NSCs could differentiate into neurons, astroglia and oligodendroglial cells.
3)Low immunogenicity: NSCs are a kind of preliminary cells that do not come to end differentiation. They do not express the antigen of mature neurocytes, thus could not be identified by the immune system.
4)Well tissue compatibility: a number of animal experiments confirmed that NSCs showed good tissue compatibility with the host nerve tissues, and could survive for a long time.
The Necessity of NSC Transplantation
Adult cerebral can produce tens of thousands neurocytes per day. Its division capacity could increase significantly when injured. These cells compensate the cell loss induced by pathological changes. However, with the sharp decreasion of these cells, especially the regeneration capacity of NSCs reduce continuously, the nerve system could not generate enough cells to compensate the cell loss of the whole body. This will trigger a series of progressive nervous system diseases, for example, CVD sequelae(Cerebral infarction and apoplexy), cerebellar atrophy, spinal cord injury, post-traumatic brain syndrom, Parkinson¡¯s Disease, Alzheimer's Disease and muscular atrophy. Traditional drugs have been applied for the treatement of the diseases mentioned above, however, they could be under control transiently because the drugs could not activate the function of cerebral neurocytes. In addition, taking drugs consistently caused great damage to the patients' health conditions, and induced some other severe complications.
Neural stem cells have the potential to differentiate into CNS, and survive in vivo after transplantation. Thus, they are the ideal material for CNS disease treatment.
To date, we have collected a series of experimental data about NSCs transplantation in the rodent and human beings for the treatment of Parkinson¡¯s Disease, Huntington Disease, spinal cord injury and ischemic stroke. According to these data, NSCs could repair the injured area and replace the cell loss successfully. The staff in our Neural Stem Cell Therapy Center have cultured a large number of NSCs in vitro, which confirms that feasibility of NSCs transplantation therapy.
Our Advantages
1)A solid backgroud of NSCs. We are an organization specialized in the NSCs transplantation therapy for nearly 10 years. The experts in our center are world famous. In addition, we have installed the most advanced technique research.
2)Our laboratory is of the first level. We have strict sterile environment and standard operation environment.
3)High quality NSCs. The NSCs cultured in our center are sufficient in number together with a high purity and activation. They could proliferate exponently and maintain their stable biological feature and therapeutic feature. Thus, they have the potential to differentiate oriently. Moreover, we have established our technique standards for NSCs culture. 4)Excellent transplantation security. Our NSCs showe low immunogenicity, which would not trigger rejection of immune system after transplantation. In addition, NSCs differentiate into neurons, astrocytes, and oligodendrocytes, thus, cause no oncogenicity after transplantation.
5)No side effects. NSCs could be used for the treatment of various diseases, e.g. Parkinson¡¯s Disease, Huntington¡¯s Disease, Multiple system sclerosis, ataxia, Alzheimer¡¯s Disease, cerebral apoplexy sequelae, post-traumatic brain syndrome, demyelinating disease, cerebral palsy, spinal cord injury, and metabolic diseases. 90% of our patients showed good treatment efficacy, and no side effects were detected.
